Vitamin B+

B vitamins are a family of water-soluble nutrients involved in many essential processes throughout the body. They act as cofactors in cellular energy production, metabolism, nervous system function, red blood cell formation, methylation, and more.*

The new Vitamin B+ was reformulated around a “right form, right dose” philosophy. Instead of maximizing doses or automatically using the most active form of every nutrient, we selected forms and amounts based on how the body actually uses them, creating a B-complex designed for everyday cellular support across a broader population.*

Different forms of vitamin B12 perform different jobs in the body, which is why Vitamin B+ intentionally includes three complementary forms instead of relying on just one. Methylcobalamin supports methylation, including the recycling of homocysteine into methionine, while adenosylcobalamin works primarily inside the mitochondria to support pathways involved in cellular energy production.*

The third form, hydroxocobalamin, acts as a versatile precursor that your cells can convert into methylcobalamin or adenosylcobalamin depending on what they need. Together, these three forms provide more comprehensive B12 support for methylation, mitochondrial function, and everyday cellular health.*

Some people report feeling overstimulated or experiencing symptoms such as restlessness, headaches, or sleep disruption with higher amounts of methylated nutrients like methylfolate, particularly when methylfolate and methylcobalamin (B12) are used together. Rather than supplying folate exclusively in a methylated form, folinic acid provides a metabolically flexible form that the body can further convert according to its needs while still supporting folate-dependent pathways, including methylation.* 

Folinic acid is an effective and well-tolerated version of vitamin B9 and makes Vitamin B+ a better fit for people who don't tolerate highly methylated formulas well.*

Vitamin B+ provides folate as folinic acid (calcium folinate), a reduced form of vitamin B9 that bypasses the initial conversion steps required for folic acid. Folinic acid can participate in folate-dependent pathways and be converted into other forms of folate.* Its conversion to methylfolate still requires the MTHFR enzyme.

Certain MTHFR gene variants, sometimes called mutations, can reduce the activity of this enzyme. However, having a variant does not automatically rule out Vitamin B+ or mean you need a methylfolate supplement. Your folate needs depend on more than your MTHFR status alone. If you are monitoring folate or homocysteine levels, your healthcare practitioner can help determine whether Vitamin B+ is a good fit.

“Methylated” doesn't automatically mean better. Some nutrients perform well in fully active forms, while others can be useful in forms that allow the body to retain more control over conversion. Vitamin B+ uses a combination of bioavailable and metabolically flexible forms selected around cellular physiology rather than ingredient trends.*

The original Vitamin B+ was designed for targeted therapeutic use and used a maximum-dose approach. The reformulated Vitamin B+ is designed for everyday cellular support across a broader population, with amounts calibrated to the nutrient form and intended use rather than simply maximizing the number on the label.*

The previous formula provided 4,000 mcg of biotin, while the new formula provides 400 mcg. Higher-dose biotin can interfere with certain laboratory tests, including some thyroid and cardiac tests, so the new amount better reflects Vitamin B+'s thoughtfully calibrated, everyday-use approach.*

Yes. Unlike the original formula, which was designed primarily for targeted therapeutic use, the new Vitamin B+ was specifically reformulated to provide everyday B-vitamin and cellular support for a broader range of people.*